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. 2017 Mar 13;18(3):624. doi: 10.3390/ijms18030624

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of mitogen-activated protein kinases (MAPKs) and phosphatidylinositol-3-kinase (PI3K) inhibitor on CXCL-8 release by F. proliferatum-stimulated BEAS-2B cells. BEAS-2B cells were pre-treated in the presence or absence of MAPKs inhibitors PD98059 (MEK1 inhibitor, 10 μM), SB202190 (p38 inhibitor, 10 μM), U0126 (ERK1/2 inhibitor, 10 μM), and SP600125 (JNK inhibitor, 5 μM) (a) and PI3K inhibitor LY294002 (5 μM) (b), respectively, for 1 h before exposure to F. proliferatum extracts (100 µg/mL) for 24 h. Supernatant was collected and the level of CXCL-8 was determined by ELISA. Results are representative of two independent experiments performed in triplicate. Asterisks (*) indicate significant differences (p < 0.05) between the paired samples.