Table 1.
Summary of miR-146b regulatory molecules and their effects in thyroid cancer cell lines.
| Regulatory Molecule/Pathway | Action | Function | Direct/Indirect | Cancer Cell Line | Cancer Subtype | Reference |
|---|---|---|---|---|---|---|
| Downregulated SMAD4 | Inhibit TGF-β anti-signal | Increase proliferation activity Inhibit cell cycle arrest | Direct | TPC-1 and BCPAP | PTC | [20] |
| Downregulated NIS | HDAC3 suppresses miR-146b | Decrease sensitivity to radioactive iodide | Direct | FTC-133 | Poorly differential thyroid carcinoma | [35] |
| Downregulated ZNRF3 | Mediated by Wnt/β-catenin signaling | Migration, invasion and EMT | Direct | TPC-1 and K1 | PTC | [36] |
| Downregulated IRAK1 | Associated with EMT process | Increase migration, proliferation | Direct | BCPAP and TPC-1 | PTC | [37] |
| Downregulated PAX8 and NIS | Decrease iodide protein translation | Decrease sensitivity to radioactive iodide | Direct | PCCl3 | PTC | [39] |
| Upregulated p21 | Cell cycle progression | Increase migration and proliferation | Indirect | FRO | ATC | [40] |
Papillary thyroid cancer; ATC, anaplastic thyroid cancer; FTC, follicular thyroid carcinoma; EMT, epithelial-mesenchymal transition.