Table 6.
Down-regulated genes differentially expressed in the liver tissue of high fat diet rats treated with insect glycosaminoglycan over a one month period.
| Description | Gene Symbol | IQG | ISG | GbG | |
|---|---|---|---|---|---|
| 1 | UDP glycosyltransferase 2 family, polypeptide B | Ugt2b | 0.10 | 1.04 | 0.92 |
| 2 | insulin-like growth factor binding protein 1 | Igfbp1 | 0.15 | 0.72 | 1.09 |
| 3 | serine dehydratase | Sds | 0.23 | 1.10 | 0.44 |
| 4 | ubiquitin D | Ubd | 0.28 | 3.21 | 0.84 |
| 5 | myelocytomatosis oncogene | Myc | 0.28 | 0.94 | 1.16 |
| 6 | insulin receptor substrate 2 | Irs2 | 0.35 | 1.02 | 1.15 |
| 7 | growth arrest and DNA-damage-inducible, gamma | Gadd45g | 0.39 | 0.99 | 2.80 |
| 8 | dual specificity phosphatase 1 | Dusp1 | 0.40 | 0.96 | 1.06 |
| 9 | early growth response 1 | Egr1 | 0.41 | 1.00 | 1.25 |
| 10 | similar to Protein C8orf4 (Thyroid cancer protein 1) (TC-1) | LOC684871 | 0.41 | 0.77 | 0.93 |
| 11 | cytokine inducible SH2-containing protein | Cish | 0.42 | 1.41 | 1.59 |
| 12 | similar to interferon regulatory factor 2 binding protein 2 | LOC679357 | 0.43 | 0.71 | 1.09 |
| 13 | solute carrier family 38, member 2 | Slc38a2 | 0.44 | 1.08 | 1.27 |
| 14 | polymerase (DNA directed), gamma 2, accessory subunit | Polg2 | 0.45 | 0.90 | 0.73 |
| 15 | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) | Got1 | 0.46 | 0.87 | 0.67 |
| 16 | hematopoietically expressed homeobox | Hhex | 0.47 | 1.11 | 1.42 |
| 17 | nuclear receptor subfamily 1, group D, member 2 | Nr1d2 | 0.48 | 1.50 | 0.75 |
| 18 | coiled-coil domain containing 52 | Ccdc52 | 0.49 | 1.02 | 1.02 |
| 19 | kininogen 1 /kininogen 1-like 1 | Kng1/Kng1l1 | 0.50 | 1.14 | 1.82 |
| 20 | WD repeat and SOCS box-containing 1 | Wsb1 | 0.50 | 0.90 | 1.04 |
| 21 | frizzled homolog 1 (Drosophila) | Fzd1 | 0.50 | 1.02 | 1.09 |
| 22 | Kruppel-like factor 6 | Klf6 | 0.50 | 1.00 | 0.79 |
| 23 | fibroblast growth factor 21 | Fgf21 | 0.51 | 0.82 | 1.17 |
| 24 | kruppel-like factor 15 | Klf15 | 0.51 | 1.00 | 0.90 |
| 25 | similar to DNA segment, Chr 16, ERATO Doi 472, expressed | RGD1563888 | 0.52 | 0.79 | 0.94 |
| 26 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | Nfkbiz | 0.52 | 0.99 | 1.08 |
| 27 | interleukin 6 receptor, alpha | I16ra | 0.52 | 0.95 | 0.92 |
| 28 | dual specificity phosphatase 1 | Duspl | 0.53 | 0.92 | 0.95 |
| 29 | Htra serine peptidase 3 | Htra | 0.53 | 0.97 | 0.94 |
| 30 | MCG147639-like | LOC100363606 | 0.53 | 0.87 | 0.79 |
Each DNA microarray ratio of IQG, ISG, or GbG is the pair mean ratio (test/control) of of B. ignitus glycosaminoglycan 10 mg/kg, I. sinclairii glycosaminoglycan 10 mg/kg, G. bimaculatus glycosaminoglycan 10 mg/kg.