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. Author manuscript; available in PMC: 2018 Jan 24.
Published in final edited form as: ACS Nano. 2016 Dec 29;11(1):927–937. doi: 10.1021/acsnano.6b07525

Figure 6.

Figure 6

In vivo cancer combination therapy with sequentially activated AQ4N-hCe6-liposome. (a) Tumor growth curves of mice after various different treatments as indicated. V and Vo stand for the tumor volumes after and before the treatment, respectively. Error bars were based on five mice in each group. (b) Average tumor weights from different groups collected at 14 d after the treatment. (c and d) H&E (c) and TUNEL staining (d) of tumor slices collected from mice from various groups at 24 h post-660 nm LED light irradiation. Groups I, II, III, IV, and V stand for saline treatment (control), hCe6-liposome + L660 nm, hCe6-liposome + free AQ4N + L660 nm, AQ4N-hCe6-liposome only, −and AQ4N-hCe6-liposome + L660 nm in (d–f), respectively. L660 nm stands for 1 h irradiation with 660 nm LED light (2 mW cm2).