Figure 2.

Bioinformatic analysis of YhhQ. (A) YhhQ is often found encoded on the genome close to Queuosine related genes. Red arrows represent preQ₁-responsive riboswitches. GluQ-RS is a Glutamyl queuosine-tRNA synthetase that produces a hyper modification of Queuosine [40]; (B) schematic representation of Escherichia coli YhhQ (P37619) illustrating the presence of the six proposed transmembrane domains, with standard identity and similarity shading, based on a sequence alignment of sequences defining the COG1738 group (Figure S2 for alignment). Image produced with TexTopo, with information from the P37619 Uniprot entry. Conserved position: ≥50% conservation; invariable: 100% conservation.