Figure 1.

Known positions of tRNA 2′-O-methylations and corresponding enzymes in Eubacteria (E. coli/Bacillus subtilis), Archaea (data almost exclusively from H. volcanii) and Eukarya (S. cerevisiae and various vertebrates). tRNAs are represented in folded 3D structures. 2′-O-methylated nucleotides are shown as spheres, orange for Eubacteria, pink for Archaea. Light blue color corresponds to yeast modifications; additional vertebrate positions are shown in dark blue. Names of homologous human proteins are in italics.