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. 2017 Feb 18;7(1):17. doi: 10.3390/biom7010017

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Sulfur delivery to the U₃₄ in cy-tRNAs and for molybdopterin (MPT) biosynthesis in eukaryotes. Multicellular eukaryotes (human and plant) possess two types of ubiquitin-like (UBL proteins, for MoCo biosynthesis, and for the thio-modification of tRNA, both of which associate with the common Uba4/MOCS3-type UBA proteins (left panel). On the other hand, the yeast Saccharomyces cerevisiae contains no MoCo biosynthesis-related proteins and only Urm1 for thio-modification of tRNAs associates to Uba4 (right panel). Sulfur atoms to be delivered are shown with filled circles.