Figure 5.

Domain structures of tRNA methyltransferases with a SPOUT fold. This figure is based on that by Tkaczuk et al. [29] and has been modified by data from recent crystal structure studies. The catalytic domain with a SPOUT fold is represented as “SPOUT”. “α” and “β” represent α-helices and β-strands, respectively. The HDPD-like domain indicates the His-Asp phosphodiesterase-like domain. S. cerevisiae: Saccharomyces cerevisiae; H. influenzae: Haemophilus influenzae; P. horikoshii: Pyrococcus horikoshii; P. abyssi: Pyrococcus abyssi; T. acidophilum: Thermoplasma acidophilum; S. acidocaldarius: Sulfolobus acidocaldarius.