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Subcellular distribution of PS ASOs and cleavage of target RNA by RNase H1. PS ASO distribute within the cell via interactions with specific proteins. Once the ASO has bound to its cognate site in the target RNA, RNase H1 (and P32) is recruited to degrade the target RNA. Post-RNase H1 cleavage and the fragments are processed by normal cellular RNA degradation pathways. PS, phosphorothioate.
