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Inhibition of c9orf72 intronic sense foci by ss-siRNAs. (A) List of ss-siRNAs that are complementary to the expanded GGGGCC repeat and controls. A mismatched base is showed in bold face and underlined. (B) Quantitation of microscopy showing the percentage of cells with RNA foci and the number of foci per 100 cells. Fifty nanomolar of ss-siRNAs were transfected into c9orf72 patient-derived fibroblast cells.
