Table 4.
Bone Mineral density (BMD) of immobilized Wistar rats.
| 7 DAYS | 14 DAYS | 28 DAYS | ANOVA | ||||||
|---|---|---|---|---|---|---|---|---|---|
| BONE | CONTROL | IMMO | CONTROL | IMMO | CONTROL | IMMO | I | T | IXT |
| LV-25 | 175.1 ± 3.9 (5) | 173.4 ± 2.6 (6) | 183.5 ± 2.4 (9) | 172.7 ± 2.2 (12) | 189.9 ± 3.5 (5) | 180.1 ± 4.2 (6) | 0.006 | 0.011 | ns |
| HUMERUS | 159.8 ± 2.1 (5) | 162.8 ± 2.2 (6) | 169.6 ± 2.9 (9) | 165.2 ± 2.0 (12) | 175.3 ± 2.0 (5) | 175.6 ± 2.6 (6) | ns | 0.001 | ns |
| FOREARM | 154.9 ± 2.3 (5) | 161.8 ± 2.5 (6) | 162.2 ± 4.7 (9) | 161.0 ± 1.9 (12) | 165.9 ± 4.6 (5) | 166.9 ± 3.0 (6) | ns | ns | ns |
| TIBIA | 150.7 ± 0.9 (5) | 150.6 ± 0.8 (6) | 159.2 ± 0.9 (8) | 152.9 ± 1.9 (12) | 165.6 ± 1.8 (5) | 164.2 ± 2.6 (6) | ns | 0.001 | ns |
| FEMUR | 196.5 ± 3.3 (5) | 198.8 ± 1.2 (6) | 208.5 ± 2.4 (9) | 201.3 ± 4.1 (12) | 219.1 ± 2.6 (5) | 213.7 ± 4.0 (6) | ns | 0.001 | ns |
Mean ± SEM for the number of animals indicated in parentheses for control (CONTROL) and immobilized (IMMO) groups are shown for every period. Bone Mineral density (BMD) was measured by peripheral Dual-energy X-ray Absorptiometry (pDEXA) analysis and expressed as mg/cm2. Statistical significance was tested by a full factorial two-way ANOVA (fixed factors: I, immobilization, T, Time; IxT denotes the interaction term). p-values are shown in the three columns on the right (ns, non-significant differences, which implies a p-value equal to or greater than 0.05).