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. 2017 Mar 29;9:73. doi: 10.3389/fnagi.2017.00073

FIGURE 2.

FIGURE 2

Network analysis. (A) Gene network analysis was performed on the top 50 most highly ranked genes identified in the meta-analysis. Input genes are shown in black circles and other genes with the greater number of interactions are displayed in gray circles. (B) Subnetwork of genes associated with hemoglobin and iron metabolism (blue circles) formed a highly interconnected co-expression network. The sizes of the gray nodes represent the degree of association with the input genes (i.e., smaller size represents low connectivity). Gene network analysis was performed in GeneMANIA using Cytoscape 3.0.3.