Table 2.
Defining melanoma-derived EV RNA cargo.
| Gene name | Gene abbreviation | Fold change (relative to primary melanocyte EV) |
|---|---|---|
| Secreted phosphoprotein 1 | SPP1 | 6.29 |
| Signal transducer and activator of transcription 1 | STAT1 | 6.17 |
| Toll-like receptor 4 | TLR4 | 6.06 |
| CD40 ligand | CD40LG | 5.24 |
| Proto-oncogene c-Maf | MAF | 4.89 |
| Toll-like receptor 6 | TLR6 | 4.47 |
| Polycomb group ring finger 2 | PCGF2 | 3.96 |
| Solute carrier family 11 member 1 | SLC11A1 | 3.74 |
| Growth factor independent 1 | GFI1 | 3.64 |
| Janus kinase 1 | JAK1 | 3.61 |
| Interleukin 9 | IL9 | 3.56 |
| Vascular endothelial growth factor A | VEGFA | 3.34 |
| CCAAT/enhancer binding protein beta | CEBPB | 3.17 |
| Interleukin 24 | IL24 | 3.17 |
Fold regulation of significant (detection threshold ≥3-fold change) genes enriched by quantitative RT-PCR in SKMEL28 EVs relative to primary melanocyte EVs (n = 3 independent experiments).