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Canonical Hippo pathway. Core components of the Hippo pathway in mammals. Mst1/2 is phosphorylated by upstream regulators and binding with Sav enhances its affinity for Lats1/2, which in turn binds with Mob1. Activation of Mst1/2 and Lats1/2 results in phosphorylation and inactivation of Yap/Taz. See text for abbreviations.
