Table 1.
Mean (95% CI) apolipoprotein concentrations according to lifestyle factors in the 9363 men and 15,621 women enrolled in the Malmö Diet and Cancer cohort.
| Variables | Men | Women | ||||||
|---|---|---|---|---|---|---|---|---|
| N | ApoA1 | ApoB | ApoB/A1 | N | ApoA1 | ApoB | ApoB/A1 | |
| All | 9363 | 1.45 (0.003) | 1.10 (0.003) | 0.78 (0.002) | 15,621 | 1.66 (0.002) | 1.06 (0.002) | 0.66 (0.002) |
| Age groups | p = 3 × 10−4 | p = 0.02 | p = 0.08 | p = 1 × 10−23 | p < 10−150 | p = 6 × 10−146 | ||
| 45–50 years | 1027 | 1.45 (0.008) | 1.08 (0.008) | 0.77 (0.007) | 4035 | 1.62 (0.004) | 0.94 (0.004) | 0.60 (0.003) |
| 50–55 years | 2280 | 1.44 (0.005) | 1.10 (0.005) | 0.78 (0.005) | 3091 | 1.64 (0.005) | 1.00 (0.004) | 0.63 (0.004) |
| 55–60 years | 1933 | 1.45 (0.006) | 1.11 (0.006) | 0.79 (0.005) | 2608 | 1.66 (0.005) | 1.06 (0.005) | 0.66 (0.004) |
| 60–65 years | 2053 | 1.47 (0.005) | 1.11 (0.006) | 0.78 (0.005) | 2823 | 1.66 (0.005) | 1.11 (0.005) | 0.69 (0.004) |
| 65–70 years | 1229 | 1.46 (0.007) | 1.11 (0.007) | 0.78 (0.006) | 1662 | 1.65 (0.007) | 1.14 (0.006) | 0.71 (0.005) |
| 70–75 years | 841 | 1.48 (0.009) | 1.11 (0.010) | 0.77 (0.008) | 1402 | 1.70 (0.008) | 1.16 (0.007) | 0.70 (0.006) |
| Education level | p = 1 × 10−4 | 3 × 10−4 | p = 4 × 10−9 | p = 3 × 10−24 | 6 × 10−39 | 6 × 10−55 | ||
| Elementary | 4188 | 1.45 (0.004) | 1.12 (0.004) | 0.79 (0.004) | 5982 | 1.63 (0.004) | 1.10 (0.003) | 0.69 (0.003) |
| Primary and secondary | 1852 | 1.47 (0.006) | 1.10 (0.006) | 0.77 (0.005) | 4780 | 1.67 (0.004) | 1.06 (0.004) | 0.66 (0.003) |
| Upper secondary | 1133 | 1.46 (0.007) | 1.09 (0.008) | 0.77 (0.007) | 1110 | 1.67 (0.008) | 1.05 (0.007) | 0.65 (0.006) |
| Further education without a degree | 897 | 1.48 (0.008) | 1.09 (0.008) | 0.76 (0.007) | 1354 | 1.68 (0.007) | 1.04 (0.007) | 0.64 (0.005) |
| University degree | 1293 | 1.47 (0.007) | 1.09 (0.007) | 0.76 (0.006) | 2395 | 1.69 (0.006) | 1.02 (0.005) | 0.62 (0.004) |
| Physical activity | 9 × 10−10 | p = 2 × 10−4 | p = 2 × 10−11 | 2 × 10−22 | p = 2 × 10−4 | 5 × 10−17 | ||
| Quintile 1 | 1858 | 1.43 (0.006) | 1.13 (0.006) | 0.81 (0.005) | 3073 | 1.62 (0.005) | 1.08 (0.004) | 0.69 (0.004) |
| Quintile 2 | 1878 | 1.45 (0.006) | 1.10 (0.006) | 0.78 (0.005) | 3142 | 1.65 (0.005) | 1.08 (0.004) | 0.67 (0.004) |
| Quintile 3 | 1877 | 1.46 (0.006) | 1.11 (0.006) | 0.78 (0.005) | 3144 | 1.66 (0.005) | 1.06 (0.004) | 0.66 (0.004) |
| Quintile 4 | 1890 | 1.47 (0.006) | 1.10 (0.006) | 0.77 (0.005) | 3130 | 1.67 (0.005) | 1.06 (0.004) | 0.65 (0.004) |
| Quintile 5 | 1860 | 1.48 (0.006) | 1.09 (0.006) | 0.75 (0.005) | 3132 | 1.68 (0.005) | 1.06 (0.004) | 0.65 (0.004) |
| BMI groups | p = 4 × 10−56 | p = 8 × 10−52 | p = 1 × 10−96 | p = 6 × 10−120 | p = 3 × 10-112 | p = 1 × 10−201 | ||
| Underweight | 52 | 1.53 (0.034) | 0.92 (0.034) | 0.61 (0.030) | 238 | 1.72 (0.017) | 0.95 (0.016) | 0.57 (0.012) |
| Normal | 3575 | 1.51 (0.004) | 1.06 (0.004) | 0.72 (0.004) | 8239 | 1.70 (0.003) | 1.03 (0.003) | 0.62 (0.002) |
| Overweight | 4628 | 1.44 (0.004) | 1.13 (0.004) | 0.80 (0.003) | 5156 | 1.62 (0.004) | 1.10 (0.003) | 0.70 (0.003) |
| Obese | 964 | 1.39 (0.008) | 1.16 (0.008) | 0.85 (0.007) | 1573 | 1.57 (0.007) | 1.15 (0.006) | 0.75 (0.005) |
| Severely obese | 145 | 1.39 (0.020) | 1.21 (0.021) | 0.89 (0.018) | 418 | 1.53 (0.013) | 1.12 (0.012) | 0.75 (0.009) |
| Alcohol habits | p = 2 × 10−123 | p = 4 × 10−6 | p = 9 × 10−19 | p = 5 × 10−155 | 2 × 10−18 | p = 1 × 10−94 | ||
| Non-consumers | 388 | 1.34 (0.012) | 1.10 (0.013) | 0.84 (0.011) | 1105 | 1.57 (0.008) | 1.09 (0.007) | 0.71 (0.006) |
| Quintile 1 | 1750 | 1.40 (0.006) | 1.09 (0.006) | 0.80 (0.005) | 2826 | 1.60 (0.005) | 1.09 (0.005) | 0.70 (0.004) |
| Quintile 2 | 1733 | 1.42 (0.006) | 1.09 (0.006) | 0.79 (0.005) | 2877 | 1.62 (0.005) | 1.08 (0.005) | 0.68 (0.004) |
| Quintile 3 | 1812 | 1.46 (0.006) | 1.10 (0.006) | 0.77 (0.005) | 2924 | 1.65 (0.005) | 1.06 (0.005) | 0.66 (0.004) |
| Quintile 4 | 1826 | 1.49 (0.006) | 1.11 (0.006) | 0.76 (0.005) | 2937 | 1.70 (0.005) | 1.05 (0.005) | 0.64 (0.004) |
| Quintile 5 | 1854 | 1.56 (0.005) | 1.13 (0.006) | 0.75 (0.005) | 2952 | 1.75 (0.005) | 1.05 (0.005) | 0.61 (0.004) |
| Smoking habits | p = 3 × 10−5 | p = 9 × 10−19 | 4 × 10−22 | p = 3 × 10−26 | 1 × 10−36 | 2 × 10−59 | ||
| Never-smokers | 2729 | 1.46 (0.005) | 1.07 (0.005) | 0.75 (0.004) | 6939 | 1.66 (0.003) | 1.06 (0.003) | 0.66 (0.002) |
| Ex-smokers | 3934 | 1.47 (0.004) | 1.11 (0.004) | 0.77 (0.004) | 4302 | 1.68 (0.004) | 1.04 (0.004) | 0.64 (0.003) |
| Smokers | 2700 | 1.44 (0.005) | 1.13 (0.005) | 0.81 (0.004) | 4380 | 1.62 (0.004) | 1.11 (0.004) | 0.71 (0.003) |
All values are adjusted for age and screening date. Differences in mean serum apolipoprotein concentrations according to lifestyle factors were tested using a general linear model. Abbreviations: Apo, apolipoprotein; BMI, body mass index.