Figure 2.

A cumulative assembly of sporadically published reports provided 607 biopsies (386 celiacs), illustrating the numerical distributions of IEL in hematoxylin and eosin (H&E) sections (red), CD3⁺ (green), and γδ⁺ (blue) immuno-subtypes,with their accompanying disease-control groups.(a) For IEL (H and E) the mean (±95% Confidence Limits) was 15 (4–26) for controls and 60 (9–111) for celiacs; (b) The results for CD3⁺ cells were 31 (0–66) for disease controls, and 66 (23–109) for celiacs; (c) For γδ⁺ cells, the mean was 23 (0–39) in the celiac group compared with 4 (0–9) for the controls. Marked overlaps between disease controls and celiac patients (indicated by the paired horizontal lines) occurred with all IEL counts: 43 for histological (H&E) counts, 110 for CD3⁺ counts, and 69 for γδ⁺ cells, respectively.