Table 1.

Methylsulfonylmethane (MSM) Toxicity Data.

Species	Route	Duration	NOAEL	Reference
Acute ≤15 days
Mice	Oral	Not stated (acute)	5 g/kg	Kocsis et al. (1975) [6]
Mice	Intraperitoneal	Not stated (acute)	5 g/kg	Kocsis et al. (1975) [6]
Mice	Oral gavage	15 days	5 g/kg	Takiyama et al. (2010) [190]
Rat	Intraperitoneal	Not stated (acute)	5 g/kg	Kocsis et al. (1975) [6]
Rat	Oral gavage	15 days	2 g/kg	Horvath et al. (2002) [187]
Subacute
Gestating Rat	Oral gavage (14 days)	21 days	1 g/kg/day	Magnuson et al. (2007) [188]
Subchronic
Mice	Oral	91 days	1.5 g/kg/day	Takiyama et al. (2010) [190]
Rat	Oral	90 days	1.5 g/kg/day	Horvath et al. (2002) [187]