Table 3.
Metabolite | Fasting State | 30 min Postprandial | 420 min Postprandial | Pooled SEM | p-Value | |||||
---|---|---|---|---|---|---|---|---|---|---|
CON | TGS | CON | TGS | CON | TGS | Diet | Time | D × T | ||
Sum of hexoses | 6204 b | 6155 b | 7526 a | 6283 b | 6496 | 6249 b | 550.8 | 0.115 | 0.170 | 0.272 |
Acylcarnitines | ||||||||||
C0 | 3.0 BD | 3.2 aAC | 3.2 AB | 3.0 bCD | 3.1 | 3.2 | 0.13 | 0.677 | 0.704 | 0.040 |
C3 | 0.04 b | 0.06 a | 0.05 b | 0.07 a | 0.04 b | 0.07 a | 0.004 | <0.001 | 0.292 | 0.874 |
C3-DC | 0.05 b | 0.09 a | 0.05 b | 0.10 a | 0.05 b | 0.11 a | 0.010 | <0.001 | 0.438 | 0.645 |
Lysophosphatidylcholines | ||||||||||
lysoPC a C16:1 | 1.7 ab | 1.8 ab | 1.8 a | 1.5 bc | 1.5 bc | 1.3 c | 0.15 | 0.110 | 0.005 | 0.117 |
lysoPC a C17:0 | 0.46 b | 0.61 a | 0.51 b | 0.50 b | 0.45 b | 0.49 b | 0.069 | 0.047 | 0.178 | 0.073 |
lysoPC a C18:1 | 21.0 | 22.8 a | 23.2 aA | 19.8 B | 19.7 | 17.6 b | 1.71 | 0.287 | 0.032 | 0.130 |
lysoPC a C18:2 | 6.3 ab | 5.4 bc | 6.9 a | 4.9 c | 6.2 ab | 4.5 c | 0.63 | <0.001 | 0.336 | 0.316 |
lysoPC a C20:3 | 1.7 B | 2.0 aA | 1.8 | 1.7 | 1.5 b | 1.5 b | 0.12 | 0.473 | 0.028 | 0.237 |
lysoPC a C20:4 | 4.1 ab | 3.8 ab | 4.3 a | 3.3 bc | 3.6 | 2.9c | 0.56 | 0.011 | 0.058 | 0.541 |
Sphingomyelins | ||||||||||
SM (OH) C14:1 | 1.2 b | 1.4 a | 1.3 | 1.2 b | 1.2 b | 1.3 | 0.10 | 0.109 | 0.721 | 0.108 |
SM (OH) C16:1 | 1.5 c | 1.9 a | 1.6 bc | 1.7 | 1.5 c | 1.8 ab | 0.21 | <0.001 | 0.651 | 0.247 |
SM (OH) C24:1 | 0.19 b | 0.25 a | 0.22 | 0.21 | 0.21 | 0.21 | 0.024 | 0.334 | 0.942 | 0.187 |
SM C18:0 | 7.5 b | 9.0 a | 7.8 b | 8.0 | 7.6 b | 8.2 | 0.61 | 0.037 | 0.626 | 0.282 |
SM C18:1 | 2.0 b | 2.5 a | 2.1 b | 2.2 | 2.0 b | 2.3 | 0.19 | 0.026 | 0.544 | 0.384 |
SM C24:1 | 9.2 b | 10.5 a | 9.8 | 9.6 | 9.7 | 9.8 | 0.55 | 0.308 | 0.951 | 0.198 |
SM C26:0 | 0.03 bc | 0.04 b | 0.06 ab | 0.07 a | 0.01 c | 0.03 b | 0.011 | 0.089 | 0.002 | 0.810 |
SEM, standard error of the mean; D × T, Diet × Time; C0, free carnitine; C3, propionylcarnitine; C3-DC, malonylcarnitine; lysoPC a, lysophosphatidylcholine with acyl residue C; SM (OH) C, hydroxysphingomyelin with acyl residue sum C; SM C, sphingomyelin with acyl residue sum C. Values are presented as least square means ± SEM; control diet, n = 6; TGS diet, n = 7. Means with different superscript letters within a row differed significantly (p < 0.05) over all sampling time points. Means with different capital superscript letters tended to differ (0.05 < p ≤ 0.10) over all sampling time points.