Table 2.

Levels of hepatic ALT, AST, and lipids in hypercholesterolemic rats.

Parameter	Control	HCD	Low-PM	Med-PM	High-PM	Sim
ALT (IU/L)	72.3 ± 4.8	117.7 ± 18.5 ##	75.8 ± 17.9 *	69.7 ± 14.7 **	93.2 ± 10.7 *	82.3 ± 14.4 *
AST (IU/L)	136.0 ± 12.9	171.3 ± 18.1 #	122.2 ± 13.9 **	103.2 ± 9.4 **	135.2 ± 11.9 *	118.4 ± 12.7 *
TG (mg/dL)	43.8 ± 4.3	140.3 ± 54.9 ##	128.6 ± 32.4 *	116.9 ± 34.5 *	89.54 ± 14.5 **	92.58 ± 16.6 *
TC (mg/dL)	41.6 ± 11.4	152.4 ± 27.1 ##	143.3 ± 32.2 *	136.5 ± 61.4 *	134.9 ± 46.8 *	127.0 ± 52.1 *

Data are expressed as mean ± SEM. Significance was measured by performing a one-way ANOVA followed by Bonferroni’s post-hoc test. ^# p < 0.05, ^## p < 0.01 vs. control. * p < 0.05, ** p < 0.01 vs. HCD-fed group. HCD, high cholesterol diet-fed group; low-, med-, and high-PM: low (1.65 × 10⁹ cfu/kg/day), medium (5.5 × 10⁹ cfu/kg/day), and high doses (1.65 × 10¹⁰ cfu/kg/day) of probiotic mixture-treated group, respectively; ALT, alanine transaminase; AST, aspartate transaminase; Sim, simvastatin-treated group; TG, triglycerides; TC, total cholesterol.