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. Author manuscript; available in PMC: 2018 Jan 10.
Published in final edited form as: Biochemistry. 2016 Dec 22;56(1):14–21. doi: 10.1021/acs.biochem.6b01144

Table 2.

Distance and Size Effects of a Gap in the Opposing Strand on AP89 Reactivity in NCPs

kdis (10−5 s−1)a t1/2 (h)a Rel. Rate
Gap : AP89b
graphic file with name nihms843680t6.jpg 1.89 ± 0.12 10.2 ± 0.7 -
graphic file with name nihms843680t7.jpg 5.66 ± 1.05 3.4 ± 0.7 3.0
graphic file with name nihms843680t8.jpg 2.50 ± 0.18 7.7 ± 0.6 1.3
graphic file with name nihms843680t9.jpg 2.16 ± 0.13 8.9 ± 0.6 1.1
graphic file with name nihms843680t10.jpg 10.13 ± 1.4 1.9 ± 0.3 5.4
a

Values presented are averages ± the standard deviation of at least three experiments each consisting of three replicates.

b

The relative rate equals the average rate constant for AP89 disappearance in a NCP containing a bistranded lesion/6.