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Reactivity of a 2-Deoxyribonolactone Abasic Site at the Dyad Axis (L73) in Various NCP Constructs
| kdis (10−5 s−1)a | t1/2 (h)a | Rel. Rate X : L73 (17)b |
|
|---|---|---|---|
 |
1.32 ± 0.09 | 14.6 ± 1.0 | - |
 |
2.12 ± 0.14 | 9.1 ± 0.6 | 1.6 |
 |
2.53 ± 0.24 | 7.6 ± 0.8 | 1.9 |
Values presented are averages ± the standard deviation of at least three experiments each consisting of three replicates.
The relative rate equals the average rate constant for L73 disappearance in a NCP containing a bistranded lesion/17.
