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Effect of 5376 on M. tuberculosis TrxR-catalyzed DTNB (5,5′-dithiobis(2-nitrobenzoic acid)) reduction by thioredoxin (TrxC). Initial rates measured at indicated TrxC and 5376 concentrations. (A) Data were fitted by non-linear regression; (B) Data on a Lineweaver–Burk plot with lines fitted by linear regression.
