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Structure–activity relationship of lead compound 5376 and its derivatives targeting drug-resistant Staphylococcus aureus.
 | ||||||||
|---|---|---|---|---|---|---|---|---|
| Compound | R | X | Y | MIC (µg/mL) MC7606 | MIC (µg/mL) MC7769 | MIC (µg/mL) MC7827 | MIC (µg/mL) MC7846 | Docking Energy (kcal/mol) |
| 5376 | O | 4-Br | 4-Cl | 2 | 4 | 8 | 4 | −9.3 |
| 5741518 | O | 4-CH3 | 4-Cl | >128 | >128 | >128 | >128 | −8.7 |
| 5870804 | O | 4-Br | H | 4 | 64 | 32 | 16 | −10.9 |
| 2082-0182 | O | H | 4-Cl | >128 | >128 | >128 | >128 | −9.0 |
| 2083-1665 | OCH3 | 4-Br | 4-Cl | >128 | >128 | >128 | >128 | −8.6 |
| 2083-1773 | O | 3-Br | 4-Cl | >128 | >128 | >128 | >128 | −9.8 |
