Table 1.
Minimal inhibitory concentrations (MICs) of AMPs and antifungal antibiotics against C. albicans. Mean (standard error, n = 3) values. The µM values in each row with the same letter are not significantly different (p < 0.05).
| 9 AMPs and 5 Anti-Fungal Antibiotics | C. albicans HMV4C | C. albicans ATCC 64124 | |||
|---|---|---|---|---|---|
| No Adhesive | Adhesive | No Adhesive | Adhesive | ||
| Human neutrophil peptide-1 (HNP-1) | µg/mL | 18.1 (0.7) | >200.0 (0.0) | 142.9 (2.4) | >1000.0 (0.0) |
| µM | 5.2 (0.2) | >58 (0.0) | 41.4 (0.7) | >290 (0.0) | |
| d | b | c | a | ||
| Human β defensin-1 (HBD-1) | µg/mL | >1000.0 (0.0) | >1000.0 (0.0) | >1000.0 (0.0) | >1000.0 (0.0) |
| µM | >254.1 (0.0) | >254.1 (0.0) | >254.1 (0.0) | >254.1 (0.0) | |
| a | a | a | a | ||
| Human β defensin-2 (HBD-2) | µg/mL | 15.1 (1.3) | >200.0 (0.0) | 20.1 (0.7) | >200.0 (0.0) |
| µM | 3.5 (0.3) | >46.1 (0.0) | 4.6 (0.2) | >46.1 (0.0) | |
| b | a | b | a | ||
| Human β defensin-3 (HBD-3) | µg/mL | 15.9 (0.4) | >200.0 (0.0) | 17.6 (0.8) | >200.0 (0.0) |
| µM | 3.1 (0.1) | >38.7 (0.0) | 3.4 (0.2) | >38.7 (0.0) | |
| b | a | b | a | ||
| Human CXCL10 (IP-10) | µg/mL | 18.6 (0.3) | >200.0 (0.0) | 103.6 (3.2) | >1000.0 (0.0) |
| µM | 2.2 (0.0) | >23.1 (0.0) | 12.0 (0.4) | >115.7 (0.0) | |
| d | b | c | a | ||
| Cathelicidin LL37 | µg/mL | 136.8 (4.5) | >1000.0 (0.0) | >1000.0 (0.0) | >1000.0 (0.0) |
| µM | 30.4 (1.0) | >222.4 (0.0) | >222.4 (0.0) | >222.4 (0.0) | |
| b | a | a | a | ||
| Sheep myeloid antimicrobial peptide 28 (SMAP28) | µg/mL | 15.7 (0.1) | >200.0 (0.0) | 14.4 (0.5) | >200.0 (0.0) |
| µM | 4.9 (0.0) | >62.5 (0.0) | 4.5 (0.2) | >62.5 (0.0) | |
| b | a | b | a | ||
| Lactoferricin B | µg/mL | 29.7 (1.1) | >1000.0 (0.0) | 23.2 (0.8) | >1000.0 (0.0) |
| µM | 9.5 (0.4) | >320.0 (0.0) | 7.4 (0.3) | >320.0 (0.0) | |
| b | a | c | a | ||
| Histatin 5 | µg/mL | 130.4 (3.0) | >1000.0 (0.0) | >1000.0 (0.0) | >1000.0 (0.0) |
| µM | 42.9 (1.0) | >329.0 (0.0) | >329.0 (0.0) | >329.0 (0.0) | |
| b | a | a | a | ||
| Nystatin (NYT) | µg/mL | 9.4 (0.2) | 137.2 (8.2) | 9.7 (0.2) | 61.0 (2.5) |
| µM | 10.2 (0.2) | 148.1 (8.9) | 10.5 (0.2) | 65.9 (2.7) | |
| c | a | c | b | ||
| Amphotericin B (AMB) | µg/mL | 5.4 (0.2) | 6.2 (1.7) | 6.0 (0.2) | 16.6 (3.1) |
| µM | 5.8 (0.2) | 6.7 (1.8) | 6.5 (0.2) | 18.0 (3.4) | |
| a | a | a | a | ||
| Chlorhexidine gluconate (CHG) | µg/mL | 6.3 (0.1) | 0.7 (0.4) | 4.1 (0.2) | 81.6 (3.2) |
| µM | 7.0 (0.1) | 0.8 (0.4) | 4.6 (0.2) | 90.9 (3.6) | |
| b | b | b | a | ||
| Chlorhexidine dihydrochloride (CHX) | µg/mL | 5.7 (0.1) | 11.1 (2.9) | 6.9 (0.1) | 4.6 (0.9) |
| µM | 9.9 (0.2) | 19.2 (5.0) | 11.9 (0.2) | 8.0 (1.6) | |
| a | a | a | a | ||
| Fluconazole (FLC) | µg/mL | 3.9 (1.5) | 8.1 (1.1) | >1000.0 (0.0) | >1000.0 (0.0) |
| µM | 12.7 (4.9) | 26.4 (3.6) | >3265.1 (0.0) | >3265.1 (0.0) | |
| b | b | a | a | ||