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Jmjd3 regulates osteoblast differentiation through transcription factors Runx2 and Osterix. BMP-2 induces Jmjd3 expression and translocation into the nucleus, where the level of H3K27me3 on the promoter regions of Runx2 and Osterix decreases by demethylation. Thus, this further promotes Msx-2 and Dlx-5 to approach to the binding sites of these promoters, resulting in the up-regulations of Runx2 and Osterix.
