Figure 5.

The in vivo tests of artesunate and artemisinin. The rats (six weeks/female) were divided into a normal group (n = 5), positive control group (n = 5/isoniazid group) and experimental groups (artesunate and artemisinin groups, n = 5/each group). The rats were orally administered with a single dose of 5 mg/kg of isoniazid, and 3.5 mg/kg of artesunate and artemisinin, once a day for four weeks, after four weeks of Mtb infection, respectively. The rats were carefully observed during the experimental periods. * p < 0.05 was considered to be statistically significant.