Algorithm 1.

Spatially varying penalty design for maximum d′

Input precomputed R

for each subgrid k = 1 to K

Construct ek with Nk unity elements (uniform spacing)

Use Eq. (5-6) to predict local PSF and covariance for Nk locations simultaneously

for each voxel j on the kth subgrid

Use Eq. (7-9) to compute MTF, NPS, and d′ at different β

Estimate β that maximizes d′

end for

end for

for each voxel not on the grid

Interpolate β based on the optimal β on the grid

end for

return a β map