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. Author manuscript; available in PMC: 2017 Mar 30.
Published in final edited form as: J Neurooncol. 2016 Feb 27;128(1):57–66. doi: 10.1007/s11060-016-2073-5

Fig. 1.

Fig. 1

Interplay of asparagine (ASN), glutamine (GLN), and branched-chain amino acids (BCAAs) in a metabolic network that affects mitochondrial energy production and nitrogen utilization. Other abbreviations: ASNS asparagine synthetase, ASP aspartate, BCAT1 branched chain amino-acid aminotransferase 1, BCKA branched chain ketoacids, GLU glutamate, GLS glutaminase, IC isocitrate, IDHWT isocitrate dehydrogenase, wild type, IDHMUT isocitrate dehydrogenase, mutated, 2HG 2-hydroxyglutarate, OA oxaloacetate