Interplay of asparagine (ASN), glutamine (GLN), and branched-chain amino acids (BCAAs) in a metabolic network that affects mitochondrial energy production and nitrogen utilization. Other abbreviations: ASNS asparagine synthetase, ASP aspartate, BCAT1 branched chain amino-acid aminotransferase 1, BCKA branched chain ketoacids, GLU glutamate, GLS glutaminase, IC isocitrate, IDHWT isocitrate dehydrogenase, wild type, IDHMUT isocitrate dehydrogenase, mutated, 2HG 2-hydroxyglutarate, OA oxaloacetate