Fig. S4.

RNA-Seq analysis of the up-/down-regulated genes and Pathways affected by BAP1 upon glucose stress. (A) Schematic diagram of RNA-Seq experiment design and analysis workflow. (B and C) The numbers of significantly altered genes [(B) BAP1 down-reglated genes; (C) BAP1 up-regulated genes (≥twofold difference)] at 0, 4, or 8 h after glucose deprivation in UMRC6 cells are indicated in Venn diagram. (D and E) The cellular pathways enriched upon BAP1 expression at each time point are indicated: (D) enriched pathways among BAP1-downreglated genes; (E) enriched pathways among BAP1 up-regulated genes. Arrows indicate UPR and oxidative stress response-related pathways.