Fig. S2.

Expansion of allograft tumor models bearing the Arf deletion and activated PB transposon for HDM201 treatment. (A) The spontaneous tumors were collected in RosaPB/+;ATP2/+;Arf^−/− animals. For each tumor, a fragment was implanted s.c. in the flank in an athymic nude mouse (passage 0). After the tumor grew, it was harvested, cut, and implanted again in an athymic nude mouse (passage 1). (B) List of 21 expanded allograft tumor models bearing the Arf deletion and activated PB transposon. The overall response to HDM201 and sequencing status are indicated for each model.