Fig. S8.

The best combinations identified with the TP53-MDM2 inhibitor CGM097. (A) A total of 51 compounds were screened in combination with CGM097 (5) in 138 TP53 wild-type cell lines. The CGM097 + ABT-263 combination exhibited the third-best combination activity (green bar). Only the 25 best combinations are represented; light-gray bars indicate a lack of statistical significance. A hit is defined as a combination with a synergy score >2 and a maximum growth inhibition >0.7 in individual cell lines over all assayed cell lines. (B) Representative examples of CGM097/ABT-263 combination responses. The percent of growth inhibition is represented in the visualization matrix. The cell line name is indicated at the top of each matrix, and the number of replicates is indicated on the right side of each matrix.