Fig. 5.

Single-cell analysis and functional model summarizing the role of WNT5A in mammary development. Scatter plot of single-cell correlation analysis of ROR2 and RYK expression in mouse MECs shows very low correlation and almost mutually exclusive expression (A), demonstrating that ROR2 and RYK are expressed in different populations of cells. Schematic illustrating the differential expression patterns of noncanonical WNT receptors in MEC populations and the signaling capacities of WNT5A acting either through ROR2 to block branching morphogenesis or through RYK to promote stem/progenitor proliferation (B).