Fig. 4.

Engineered RBCs in EAE mouse models. (A) Mean EAE clinical scores of mice subjected to transfusion with RBC-MOG_35–55, RBC-OVA_323–339, unconjugated MOG_35–55 peptide, or saline at 7 d before induction of EAE. Mean clinical scores of mice subjected to therapy by transfusion of RBC-MOG_35–55 (or RBC-OVA_323–339 as control) into (B) mice at preclinical stage and (C) mice with a clinical EAE score of 1; the black arrows indicate time of RBC administration. **P < 0.01, two-way ANOVA with repeated measures. All pair-wise comparisons were performed; RBC-MOG_35–55 was shown to be significantly different from other treatment groups.