Fig. 5.

pH-dependent deactivation is found across ASIC1a but not ASIC1a/2a heteromers. (A) Representative responses to triple-jump protocol from patches expressing rat ASIC1a (Upper Left), hASIC1a (Upper Right), cASIC1a (Lower Right), or rat ASIC1a/2a (Lower Left) heteromers. (B) Summary of weighted deactivation time constants from the constructs in A. Note that time constants for kinetics at more acidic pHs are dictated by the desensitization process, and hence not reported here. Data are from between four and 22 patches. Error bars show SEM.