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. Author manuscript; available in PMC: 2017 Aug 6.
Published in final edited form as: Nat Microbiol. 2017 Feb 6;2:16276. doi: 10.1038/nmicrobiol.2016.276

Figure 2. Chronic infections are characterized by the expression of distinctive clusters of pir genes in P. chabaudi.

Figure 2

(A) Chronic Associated Pir Loci (ChAPL), and (B) Acute Associated Pir Loci (AAPL) are shown in the context of the subtelomeric region from the telomeric repeats to the last pir or fam-a gene. Those genes co-expressed across mice over the course of infection are highlighted in orange. (C) Heatmap of pir gene expression at ChAPL and AAPL loci, showing mean-normalised RPKM values for 10 wild type C57Bl/6 mice, four B6.μMT-/- mice and three TCRα-/- mice infected by mosquito bites. Each column represents values obtained from an individual mouse. Samples were collected from the same mice during the acute and chronic (chro.) phases of infection. On the side, numbers indicate chromosomes and letters indicate the location on that chromosome: L for left hand end, R for right hand end. ChAPLs and AAPLs are highlighted. For each gene, red represents its maximal expression, green its minimal expression. The absolute maximum and minimum values for each gene are shown in a separate heatmap.