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. Author manuscript; available in PMC: 2017 Aug 6.
Published in final edited form as: Nat Microbiol. 2017 Feb 6;2:16276. doi: 10.1038/nmicrobiol.2016.276

Figure 4. Chronicity and virulence of infection are dictated by the initial composition of P. chabaudi population.

Figure 4

Parasites tagged with mCherry (Fluo 1) were Mosquito-Transmitted (MT), and mNeonGreen (Fluo 2) tagged parasites were Serially Blood-Passaged (SBP). Different proportions of the two were used to infect recipient mice by i.p. injection of 105 parasites (n= 10 mice per group). As a control, a group of 10 recipient mice was infected by i.p. injection of 104 SBP parasites. The mean percentage of parasites being SBP (as determined by flow cytometry) is indicated (upper panel). We show maximum parasitaemia, temperature change, weight change (middle panel) and time of recrudescence (lower panel) for each group compared to mice infected with 100% MT parasites (blue dotted line) or 100% SBP parasites (red dotted line). Each dot represents the mean ± standard error of the mean (SEM) for each group of 10 mice. Each group has been compared to mice infected with 105 SBP parasites (*P<0,05; **P<0,01; ***P<0,001, two-sided Mann Whitney Test).