Table 6.
Univariable and multivariable Cox proportional hazards modeling of 10-year incidence of acute rejection in the nested case-control analysis (n=40)
| Parameter | Univariable HR (95% CI) | P Value | Multivariable HR (95% CI) | P Value |
|---|---|---|---|---|
| FN/Col-IV antibody positive (negative as reference category) | 4.81 (0.97 to 23.89) | 0.05 | 5.79 (1.04 to 32.33) | <0.05 |
| Polyomavirus status (no BK/JC reactivation as reference category) | 0.95 (0.19 to 4.69) | 0.95 | ||
| Cyclosporin-based regimen (tacrolimus as reference category) | 0.74 (0.15 to 3.69) | 0.72 | 0.68 (0.13 to 3.58) | 0.65 |
| Age at transplant, yr | 0.97 (0.92 to 1.02) | 0.22 | 0.97 (0.92 to 1.02) | 0.21 |
| HLA mismatches, number | 0.86 (0.56 to 1.33) | 0.49 | ||
| Black race (nonblack race as reference category) | 0.95 (0.12 to 7.71) | 0.96 | 1.85 (0.19 to 17.66) | 0.60 |
| Deceased donor type (living donor as reference category) | 1.94 (0.39 to 9.63) | 0.42 | ||
| Men (women as reference category) | 0.47 (0.09 to 2.33) | 0.47 |
Univariable and multivariable Cox proportional hazards models were constructed for acute rejection because it was the only outcome that was significant at P<0.05 level by Kaplan–Meier analysis. The final multivariable model used forced entry of FN/Col-IV antibody status, calcineurin inhibitor, age at transplant, and race regardless of their performance in univariable analysis, because they were covariates of interest in the larger cohort analysis. HR, hazard ratio; 95% CI, 95% confidence interval.