Table 5.
Associations (HRs and 95% CIs) of FGF23 with first infection-related hospitalization for the 881 participants in a random subgroup with measurements of markers of mineral metabolism
| Model | Quartile 1 <53.34 RU/ml, n=223 | Quartile 2 =53.34–70.34 RU/ml, n=228 | Quartile 3 =70.35–99.33 RU/ml, n=220 | Quartile 4 >99.33 RU/ml, n=210 | Per Doubling of FGF23 |
|---|---|---|---|---|---|
| Model 1 | Reference | 1.25 (0.90 to 1.73) | 1.50 (1.08 to 2.08) | 2.96 (2.15 to 4.09) | 1.61 (1.43 to 1.81) |
| Model 2 | Reference | 1.10 (0.79 to 1.53) | 1.34 (0.96 to 1.88) | 2.19 (1.54 to 3.13) | 1.42 (1.24 to 1.63) |
| Model 3 | Reference | 1.07 (0.77 to 1.49) | 1.27 (0.91 to 1.79) | 2.07 (1.44 to 2.97) | 1.37 (1.19 to 1.57) |
| Model 4a | Reference | 1.04 (0.75 to 1.45) | 1.24 (0.88 to 1.75) | 2.02 (1.41 to 2.91) | 1.35 (1.17 to 1.55) |
| Model 4b | Reference | 1.04 (0.74 to 1.45) | 1.25 (0.89 to 1.75) | 1.99 (1.38 to 2.86) | 1.34 (1.17 to 1.55) |
Model 1: age, race, and sex. Model 2: model 1, smoking status, BMI, diabetes, CHD, CHF, eGFR (cystatin C equation), and urine ACR. Model 3: model 2, albumin, CRP, and IL-6. Model 4a: model 3, calcium, phosphorus, 25(OH)D, iPTH, and 24,25(OH)2D. Model 4b: model 3, calcium, phosphorus, iPTH, and the VMR [24,25(OH)2D-to-25(OH)D ratio]. RU, relative unit.