Figure 1.

Benefits of finerenone (10 mg/kg) for preventing kidney injury induced by IR. Renal function was evaluated by quantifying the plasma levels of (A) creatinine and (B) urea. As markers of tubular injury, (C) levels of mRNA in the kidney for neutrophil gelatinase-associated lipocalin and (D) kidney injury molecule-1 were assessed by RT-PCR. Representative hematoxylin and eosin staining images are shown for the (E) sham, (F) IR, and (G) IR and finerenone (IR+Fine) groups. (H) The percentage of injured tubules was quantified blind, on ten fields per mouse. Scale bar, 20 μm. n=8 per group. One-way ANOVA was performed. ***P<0.001; ****P<0.001.