Schematic representation of study design and delivery. (A) Crossover, randomized, controlled trial design. Patients were randomized to HD or HDF for 2 weeks, after which they attended a cardiac MRI scan that was performed before, during, and after a dialysis session. Thereafter, participants switched to the other treatment for another 2 weeks, after which cardiac MRI assessment was again performed. (B) Details of cardiac MR scan sessions are shown, with the timing of the acquisition of each of the multiple MRI measures of cardiac structure and function that were collected in each 50-minute MR scan session. PCA, phase contrast angiography.