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. Author manuscript; available in PMC: 2017 May 5.
Published in final edited form as: Cell. 2016 May 5;165(4):896–909. doi: 10.1016/j.cell.2016.04.039

Figure 2. The circadian metabolome is reorganized by lung cancer.

Figure 2

A) Heat maps displaying oscillating metabolites as determined by JTK_cycle (p-value <0.05) in WT and TB mice. Left panels display circadian metabolites exclusively in WT liver and right panels show metabolites with more robust oscillation in TB mice. B) Two-way ANOVA analysis using a p-value cutoff of 0.05 reveals metabolites that are responsive to lung tumors, circadian time point, or both. Numbers of oscillating metabolites using JTK_cycle are indicated from WT, TB or BOTH categories. C) Phase analysis was performed using JTK_cycle to identify the phase of peak metabolite expression. D) Oscillating metabolites are displayed based on biological sub-pathway, including amino acid, carbohydrate, cofactors, lipids, nucleotides, peptides and xenobiotics. E) Examples of energetic metabolites that are dampened in TB mice. NAD+= nicotinamide adenine dinucleotide; ATP= adenosine 5′-triphosphate.