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. Author manuscript; available in PMC: 2017 May 5.
Published in final edited form as: Cell. 2016 May 5;165(4):896–909. doi: 10.1016/j.cell.2016.04.039

Figure 7. Lung adenocarcinoma distally rewires circadian hepatic metabolism.

Figure 7

Schematic overview depicting the effects of the tumor macroenvironment on circadian hepatic metabolism. Our results show that lung tumors, acting through the inflammatory STAT3-Socs3 axis, operate to distally rewire circadian transcription and metabolism by acting as an endogenous circadian organizer (ECO). This manifests in loss of hepatic insulin signaling, glucose intolerance, and deregulated lipid metabolism through the AMPK/SREBP pathway.