Table 4.
BMI Intercept (at Age 62) and Slope Derived from Latent Growth Modeling as Predictors of Cardiometabolic Outcomes at Age 62
| Hypertension Odds Ratio (95% CI) |
Diabetes Odds Ratio (95% CI) |
Dyslipidemia Odds Ratio (95% CI) |
Inflammation Odds Ratio (95% CI) |
Ischemic Heart Disease Odds Ratio (95% CI) |
|
|---|---|---|---|---|---|
| Intercept (BMI Age 62) | 1.08 (0.97, 1.20) | 1.02 (0.93, 1.12) | 0.97 (0.88, 1.07) | 1.00 (0.91, 1.10) | 0.99 (0.88, 1.10) |
| Linear slope (BMI) | 1.10 (0.88, 1.38) | 1.29 (1.05, 1.60) | 1.42 (1.13, 1.80) | 1.25 (0.99, 1.58) | 1.24 (0.94, 1.63) |
| Quadratic slope (BMI) | 1.48 (0.65, 3.40) | 0.63 (0.28, 1.42) | 0.85 (0.36, 1.98) | 1.24 (0.59, 2.63) | 0.61 (0.25, 1.46) |
| Age (VETSA 2) | 1.03 (0.96, 1.10) | 1.04 (0.97, 1.11) | 1.00 (0.94, 1.07) | 1.04 (0.98, 1.12) | 0.93 (0.86, 1.01) |
| Education (Lifetime years) | 1.02 (0.94, 1.11) | 1.00 (0.93, 1.08) | 0.97 (0.89, 1.05) | 1.04 (0.96, 1.13) | 0.98 (0.89, 1.07) |
| Ethnicity (Non-Hispanic White vs. other) |
1.06 (0.62, 1.81) | 1.01 (0.63, 1.62) | 1.36 (0.79, 2.33) | 0.82 (0.49, 1.36) | 1.12 (0.61, 2.07) |
| Smoking (VETSA 2) | |||||
| Current smokers vs. Never smokers | 0.98 (0.61, 1.57) | 0.90 (0.58, 1.38) | 1.51 (0.94, 2.44) | 2.96 (1.92, 4.56) | 2.79 (1.57, 4.94) |
| Former smokers vs. Never smokers | 1.16 (0.80, 1.69) | 1.20 (0.85, 1.69) | 1.17 (0.82, 1.65) | 1.00 (0.69, 1.46) | 2.83 (1.79, 4.50) |
Notes: BMI=Body Mass Index (kg/m2); inflammation measured with high sensitivity C-Reactive Protein; Models include intercept (age 20 BMI), Age (years), education (Lifetime in years), ethnicity (0=other; 1=non-Hispanic white) and smoking (0= Never smokers; 1= Former smokers; 2= Current smokers; Never smoker as reference group) as covariates in models with family (twin clustering) as a random effect. Bold indicates values significant with 95% CI. Age measured in years. CI=confidence interval. Age centered at 62 years. VETSA 2 measures = Age 62; BMI intercept and slope derived from empirical Bayes estimates.