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. Author manuscript; available in PMC: 2017 Mar 30.
Published in final edited form as: Cell Metab. 2016 Mar 8;23(3):467–478. doi: 10.1016/j.cmet.2016.02.003

Figure 5. Controls BAT activation by the VMH clock involves efferent signals via sympathetic nervous system.

Figure 5

A) Rectal temperature B) β-oxidation rate in response to the ADRB3 antagonist SR59230A. C) Percent change on the expression of thermogenic genes by blocking the ADRB3 D) Time-response on the rectal temperature by exposition of the mice to cold temperature. E-H) Effect of cold exposure on the expression of Nrf1, Cpt1b, Ucp1 and Ucp2 in BAT. Sf1-,Cre;Bmal1loxP/loxP, (red symbols);Bmal1loxP/loxP, (black symbols). (* < 0.05, ** < 0.001, A, B, D, t-test in; C, Two-way ANOVA followed by Bonferroni’s post hoc test). All plots expressed as means ± SEM. n=5 per group. Sf1-Cre;Bmal1loxP/loxP, red bars, lines and symbols; Bmal1loxP/loxP, black bars, lines and symbols.