Table 3. Top hits from the genome-wide screen for Achilles tendon injury and ACL rupture (p<1x10-6).
Achilles tendon injury | ||||||
SNP | EAa | MAFb | P (FE)c | OR (FE)(95% CI)d | P (RE) | OR (RE) (95% CI) |
rs1937810 | C | 0.17 | 1.5x10-7 | 1.16 (1.11–1.21) | 1.5x10-7 | 1.16 (1.11–1.21) |
rs57104447 | C | 0.04 | 3.0x10-7 | 1.28 (1.19–1.37) | .01 | 1.25 (1.16–1.34) |
rs57224706 | G | 0.03 | 6.0x10-7 | 1.36 (1.24–1.48) | 6.0x10-7 | 1.36 (1.24–1.48) |
rs60713544 | C | 0.02 | 7.2x10-7 | 1.43 (1.29–1.57) | 7.2x10-7 | 1.43 (1.29–1.57) |
ACL rupture | ||||||
SNP | EAa | MAFb | P (FE)c | OR (FE) (95% CI)d | P (RE) | OR (RE) (95% CI) |
rs4067493 | G | 0.04 | 2.4x10-7 | 1.94(1.69–2.19) | 3.1x10-5 | 2.06(1.81–2.31) |
rs113435565 | C | 0.03 | 4.0x10-7 | 1.91 (1.66–2.16) | 4.0x10-7 | 1.91 (1.66–2.16) |
rs11960097 | G | 0.08 | 5.9x10-7 | 1.54 (1.37–1.71) | 5.9x10-7 | 1.54 (1.37–1.71) |
aEffect allele.
bMinor Allele Frequency in the control population.
cP-value from fixed effects (FE) or random effects (RE) meta-analysis.
dAllelic odds ratio (95% confidence interval) for the effect allele. FE, fixed effect; RE, random effect.