Table 3. Prognostic factors predicting overall disease-free survival in all patients with papillary thyroid carcinoma.

Variable	Univariate analysis	Multivariate analysis
	p-value	HR	95% CI	p-value
Age (≥ 45 years)	0.070	0.674	0.323–1.407	0.294
Sex (male)	0.310	0.924	0.398–2.145	0.854
Aggressive variant	0.048	1.774	0.523–6.014	0.357
pT (T1-2 vs. T3-4)	0.027	1.667	0.552–5.031	0.365
Lymph node metastasis	< 0.001	1.402	0.569–3.455	0.463
Lateral LN metastasis	< 0.001	3.690	1.824–7.465	< 0.001
Dyscohesive cells	0.031	1.731	0.655–4.580	0.269
Psammoma body	0.022	1.819	0.826–4.005	0.138
BRAF V600E mutation	0.872	0.978	0.386–2.477	0.962

Aggressive variants included 21 tall cell variants and 1 hobnail variant. Presence of dyscohesive cells in ≥ 1% of the tumor periphery and invasive front was categorized as positive. Presence of psammoma body was considered as positive when its number was more than 3. LN, lymph node.