Table 4. Multivariate analysis for prognostic factors predicting disease-free survival of patients with papillary thyroid carcinoma according to tumor size category.
| Variable | < 2.0 cm (n = 402) | ≥ 2.0 cm (n = 110) | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | |
| Age (≥ 45 years) | 0.481 | 0.198–1.169 | 0.106 | 0.796 | 0.272–2.331 | 0.677 |
| Sex (male) | 1.381 | 0.460–4.149 | 0.565 | 3.906 | 1.204–12.674 | 0.023 |
| Aggressive variant | 0.720 | 0.094–5.536 | 0.752 | 7.613 | 1.816–31.923 | 0.006 |
| Lateral LN metastasis | 4.173 | 1.758–9.905 | 0.001 | 2.150 | 0.703–6.576 | 0.180 |
| 2 Risk factors* | ||||||
| 0 vs 1 Risk factor | 1.877 | 0.527–6.686 | 0.332 | 2.688 | 0.754–9.586 | 0.127 |
| 0 vs 2 Risk factors | 2.984 | 0.707–12.594 | 0.137 | 13.303 | 2.175–81.357 | 0.005 |
*Two risk factors included dyscohesive cells ≥ 1% with psammoma body ≥ 4 in tumor < 2.0 cm and dyscohesive cells ≥ 20% with psammoma body ≥ 4 in tumor ≥2.0 cm.
HR, hazard ratio; CI, confidence interval; LN, lymph node.