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. 2017 Mar 30;12(3):e0174778. doi: 10.1371/journal.pone.0174778

Fig 7. Association between H63D or C282Y HFE polymorphisms and HFE gene expression for survival of TCGA GBM patients.

Fig 7

(A) Survival curve of TCGA GBM based on HFE gene expression. GBM patients who express high level (>50%) of HFE gene had poorer survival than those with low (<50%) HFE gene expression (p = 0.03). (B) Sample number and mean HFE gene expression level of TCGA GBM patients who have WT or H63D or C282Y HFE polymorphisms. The HFE gene expression value is the log2 of the normalized fluorescence intensity. (C) HFE gene expression in GBM patients who have WT or H63D HFE polymorphisms. 0/0 –no mutation for H63, 0/1 –heterozygote of H63D, 1/1 –homozygote of H63D. Y axis is HFE gene expression value. (D) HFE gene expression of GBM patients who have WT or C282Y HFE polymorphisms. 0/0 –no mutation for C282Y, 0/1 –heterozygote of C282Y, 1/1 –homozygote of C282Y. Y axis is HFE gene expression value.