Table 4. Allele and genotype frequencies of H63D and C282Y HFE polymorphisms in our previous study1 and TCGA GBM (TP, NB) samples1, stratified by gender.
| PSHCI GBM (n = 97)2 | TP (n = 264) | NB (n = 261) | ||||
|---|---|---|---|---|---|---|
| Male (n = 49) | Female (n = 48) | Male (n = 167) | Female (n = 97) | Male (n = 164) | Female (n = 97) | |
| Genotype | ||||||
| H63D/+ | 9 (18.4%) | 9 (18.8%) | 40 (24.0%) | 21 (21.6%) | 39 (23.8%) | 21 (21.6%) |
| H63D/H63D | 0 (0.0%) | 1 (2.1%) | 4 (2.4%) | 2 (2.1%) | 4 (2.4%) | 2 (2.1%) |
| C282Y/+ | 2 (4.1%) | 4 (8.3%) | 9 (5.4%) | 6 (6.2%) | 9 (5.5%) | 7 (7.2%) |
| C282Y/C282Y | 0 (0.0%) | 0 (0.0%) | 2 (1.2%) | 0 (0.0%) | 1 (0.6%) | 0 (0.0%) |
| H63D/C282Y | 0 (0.0%) | 0 (0.0%) | 2 (1.2%) | 1 (1.0%) | 2 (1.2%) | 1 (1.0%) |
| +/+ | 38 (77.6%) | 34 (70.8%) | 110 (65.9%) | 67 (69.1%) | 109 (66.5%) | 66 (68.0%) |
| Alleles | ||||||
| H63D | 9/98 (9.2%) | 11/96 (11.5%) | 50/334 (15.0%) | 26/194 (13.4%) | 49/328 (14.9%) | 26/194 (13.4%) |
| C282Y | 2/98 (2.0%) | 4/96 (4.2%) | 15/334 (4.5%) | 7/194 (3.6%) | 13/328 (4.0%) | 8/194 (4.1%) |
1 Caucasian only, Values were expressed as n = N (%) or n = N
2 Lee SY, et al. J Neurooncol. 2015; 122: 97–104.