Fig. 3.

First dimension of the left uncinate fasciculus Isomap. (Top) Moving average shapes (MAS) along the Isomap observed with 2 different orientations (for each orientation, the frontal horn of the bundle is on the left). The extreme MAS (green and magenta) are combined to highlight the shape feature encoded by the Isomap. This dimension captures the volume variability of the bundles. From the left to the right of the Isomap axis, the volume increases, while the bundle becomes more “fanned out” in the frontal lobe. More particularly, the ventrolateral orbitofrontal branch emerges toward the right of the axis. (Middle) Individual bundles are superimposed over the same MAS along the Isomap axis to show their distributions for both groups. (Bottom) Uncinate fasciculus sample and overall and centre-based boxplots of the localization in the isomap after adjustment for fractional anisotropy, age and sex.